| Date | Opponent / Event | Location | Time / Result | Media | |
|
| 09/11/10 | vs. Georgetown (Appreciation Night) * | Easton, Pa. | L, 28-24 | TV: LSN (RCN-4, RCN-8, WBPH-60, delay on MASN) | More |
| 09/18/10 | at Penn | Philadelphia, Pa. | L, 19-14 | Watch TV: LSN (RCN-4, RCN-8, WBPH-60, ESPN3.com , delay on MASN) | More |
| 09/25/10 | at Princeton | Princeton, N.J. | L, 36-33 (2OT) | Princeton LiveStats TV: LSN (RCN-4, RCN-8, WBPH-60, ESPN GamePlan, delay on MASN) | More |
| 10/02/10 | vs. Harvard (Family Weekend) | Easton, Pa. | L, 35-10 | TV: LSN (RCN-4, RCN-8, WBPH-60, delay on MASN) | More |
| 10/09/10 | at Columbia | New York, N.Y. | L, 42-28 | TV: LSN (RCN-4, RCN-8, WBPH-60, ESPN GamePlan, delay on MASN) | More |
| 10/16/10 | vs. Stony Brook (Homecoming) | Easton, Pa. | W, 28-21 | TV: LSN (RCN-4, RCN-8, WBPH-60, delay on MASN) | More |
| 10/23/10 | at Fordham * | Bronx, N.Y. | L, 14-10 | TV: LSN (RCN-4, RCN-8, WBPH-60, delay on MASN) | More |
| 10/30/10 | at Bucknell * | Lewisburg, Pa. | W, 33-12 | TV: LSN (RCN-4, RCN-8, WBPH-60, delay on MASN) | More |
| 11/06/10 | at Colgate * | Hamilton, N.Y. | L, 24-14 | TV: LSN (RCN-4, RCN-8, WBPH-60, delay on MASN) | More |
| 11/13/10 | vs. Holy Cross (Chili Cook-Off) * | Easton, Pa. | L, 37-27 | TV: LSN (RCN-4, RCN-8, WBPH-60, delay on MASN) | More |
| 11/20/10 | vs. Lehigh (146th meeting) * | Easton, Pa. | L, 20-13 | ESPN3.com TV: LSN (ESPN GamePlan: DirecTV 788, DISH 455, RCN-4&8, WBPH-60) | More |
| 04/16/11 | vs. Maroon vs. White Spring Scrimmage | Fisher Stadium | W, 33-21 | | More |
