| Date | Opponent / Event | Location | Time / Result | Media | Â |
|
| 09/08/12 | at William & Mary | Williamsburg, Va. | W, 17-14 | TV: LSN (ESPN GamePlan, ESPN3, RCN-TV, WBPH-60, GoLeopards.com) | More |
| 09/15/12 | vs. Penn (Student Appreciation Night/Block pARTy) | Easton, Pa. | W, 28-21 | TV: LSN (RCN-TV, WBPH-60, GoLeopards.com) | More |
| 09/22/12 | at Bucknell * | Lewisburg, Pa. | W, 20-14 | TV: CBS Sports Network | More |
| 09/29/12 | at Robert Morris | Moon Township, Pa. | L, 31-28 | | More |
| 10/06/12 | vs. Princeton (RCN Community Night) | Easton, Pa. | L, 35-14 | TV: LSN (RCN-TV, WBPH-60, GoLeopards.com) | More |
| 10/13/12 | at Yale | New Haven, Conn. | W, 20-10 | Yale Live Stats  TV: LSN (ESPN GamePlan, ESPN3, RCN-TV, WBPH-60, GoLeopards.com) | More |
| 10/20/12 | vs. Holy Cross (Homecoming) * | Easton, Pa. | W, 30-13 | TV: LSN (RCN-TV, WBPH-60, GoLeopards.com) | More |
| 10/27/12 | vs. Georgetown (Family Weekend) * | Easton, Pa. | L, 20-17 | TV: LSN (RCN-TV, WBPH-60, GoLeopards.com) | More |
| 11/03/12 | at Colgate * | Hamilton, N.Y. | L, 65-41 | Colgate Live Stats  TV: LSN (RCN-TV, WBPH-60, GoLeopards.com) | More |
| 11/10/12 | at Fordham | Bronx, N.Y. | L, 36-27 | TV: LSN (RCN-TV, WBPH-60, GoLeopards.com) | More |
| 11/17/12 | vs. Lehigh (148th Meeting) * | Easton, Pa. | L, 38-21 | TV: LSN (MASN2, RCN-TV, WBPH-60, GoLeopards.com) | More |